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Dose optimization of early high-dose valproic acid for neuroprotection in a swine cardiac arrest model

Aim: High-dose valproic acid (VPA) improves the survival and neurologic outcomes after asphyxial cardiac arrest (CA) in rats. We characterized the pharmacokinetics, pharmacodynamics, and safety of high-dose VPA in a swine CA model to advance clinical translation. Methods: After 8 ​min of untreated v...

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Автори: Cindy H. Hsu, Mohamad H. Tiba, Brendan M. McCracken, Carmen I. Colmenero, Zachary Pickell, Danielle C. Leander, Anne M. Weitzel, Sarita Raghunayakula, Jinhui Liao, Tulasi Jinka, Brandon C. Cummings, Manjunath P. Pai, Hasan B. Alam, Kevin R. Ward, Thomas H. Sanderson, Robert W. Neumar
Формат: Artigo
Мова:Inglês
Опубліковано: Elsevier 2020-03-01
Серія:Resuscitation Plus
Предмети:
Cardiac arrest
Swine model
Valproic acid
Histone acetylation
Pharmacokinetic
Pharmacodynamics biomarker
Онлайн доступ:http://www.sciencedirect.com/science/article/pii/S2666520420300072
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