Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.

Eukaryotic cells have evolved to use complex pathways for DNA damage signaling and repair to maintain genomic integrity. RNF168 is a novel E3 ligase that functions downstream of ATM,γ-H2A.X, MDC1, and RNF8. It has been shown to ubiquitylate histone H2A and to facilitate the recruitment of other DNA...

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Hlavní autoři:	Toshiyuki Bohgaki, Miyuki Bohgaki, Renato Cardoso, Stephanie Panier, Dimphy Zeegers, Li Li, Grant S Stewart, Otto Sanchez, M Prakash Hande, Daniel Durocher, Anne Hakem, Razqallah Hakem
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2011-04-01
Edice:	PLoS Genetics
On-line přístup:	https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001381&type=printable
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