Assessing the effect of therapeutic level of oxytetracycline dihydrate on pharmacokinetics and biosafety in Oncorhynchus mykiss (Walbaum, 1792)

Abstract The aim of the experiment was to investigate the pharmacokinetics of oxytetracycline dihydrate after a single oral administration of 80 mg kg−1 day−1 in rainbow trout and assess its biosafety at concentration of 80, 240, 400, and 800 mg kg−1 day−1 over 30 days, focusing on various aspects s...

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Principais autores:	Richa Pathak, Sumanta Kumar Mallik, Prasanna Kumar Patil, Krishna Kala, Neetu Shahi, Ranjit Kumar Nadella, Nityanand Pandey, Kishor Kunal, Pramod Kumar Pandey
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2024-10-01
Series:	Scientific Reports
Assuntos:	Oxytetracycline dihydrate Rainbow trout Drug absorption kinetics Antibiotic residue Non-compartmental analysis
Acceso en liña:	https://doi.org/10.1038/s41598-024-73921-8
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