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Dural lymphatics regulate clearance of extracellular tau from the CNS

Abstract Background Alzheimer’s disease is characterized by two main neuropathological hallmarks: extracellular plaques of amyloid-β (Aβ) protein and intracellular aggregates of tau protein. Although tau is normally a soluble monomer that bind microtubules, in disease it forms insoluble, hyperphosph...

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Autori principali: Tirth K. Patel, LeMoyne Habimana-Griffin, Xuefeng Gao, Baogang Xu, Samuel Achilefu, Kari Alitalo, Celia A. McKee, Patrick W. Sheehan, Erik S. Musiek, Chengjie Xiong, Dean Coble, David M. Holtzman
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2019-02-01
Serie:Molecular Neurodegeneration
Soggetti:
Alzheimer’s disease
Tau
Tauopathy
Neurodegeneration
Dural lymphatic system
Glymphatic system
Accesso online:http://link.springer.com/article/10.1186/s13024-019-0312-x
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