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Phosphatidylcholine Ameliorates Palmitic Acid‐Induced Lipotoxicity by Facilitating Endoplasmic Reticulum and Mitochondria Contacts in Intervertebral Disc Degeneration

ABSTRACT Background Intervertebral disc degeneration (IDD) is a prevalent musculoskeletal disorder with substantial socioeconomic impacts. Despite its high prevalence, the pathogenesis of IDD remains unclear, and effective pharmacological interventions are lacking. This study aimed to investigate me...

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Principais autores: Shuangshuang Tu, Yijun Dong, Chuanfu Li, Mingxin Jiang, Liqun Duan, Wenzhi Zhang, Xi Chen
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2025-06-01
Serier:JOR Spine
Fag:
cell senescence
IDD
lipotoxicity
palmitic acid
phosphatidylcholine
Online adgang:https://doi.org/10.1002/jsp2.70062
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