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Mitochondrial dysfunction in chromaffin cells from the R6/1 mouse model of Huntington's disease: Impact on exocytosis and calcium current regulation

From a pathogenic perspective, Huntington's disease (HD) is being considered as a synaptopathy. As such, alterations in brain neurotransmitter release occur. As the activity of the sympathoadrenal axis is centrally controlled, deficits in the exocytotic release of catecholamine release may also occu...

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Principais autores: Ana Fernández, Carmen Martínez-Ramírez, Ana Gómez, Antonio M.G. de Diego, Luis Gandía, María José Casarejos, Antonio G. García
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-04-01
Serier:Neurobiology of Disease
Fag:
Huntington's disease
R6/1 mouse
Chromaffin cells
Mitochondria
Exocytosis
Calcium channels
Online adgang:http://www.sciencedirect.com/science/article/pii/S0969996123000608
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