The β-adrenergic receptor-SGK1 signaling pathway in brown adipocytes protects GOT1 from proteasomal degradation

The malate-aspartate shuttle (MAS) is a key biochemical system that facilitates the transfer of reducing equivalents from the cytosol into mitochondria. It consists of two pairs of cytosolic and mitochondrial enzymes: glutamic-oxaloacetic transaminases (cGOT1, mGOT2) and malate dehydrogenases (cMDH1...

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Главные авторы:	Chul-Hong Park, Minsung Park, J. Jason Collier, Ji Suk Chang
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2025-07-01
Серии:	Frontiers in Cell and Developmental Biology
Предметы:	beta-adrenergic receptor SGK1 GOT1 Brown adipose tissue (BAT) malate-aspartate shuttle (MAS) signaling/signaling pathways
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1637770/full
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