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Inhibitors of the Cancer Target Ribonucleotide Reductase, Past and Present

Ribonucleotide reductase (RR) is an essential multi-subunit enzyme found in all living organisms; it catalyzes the rate-limiting step in dNTP synthesis, namely, the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. As expression levels of human RR (hRR) are high during c...

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Principais autores: Sarah E. Huff, Jordan M. Winter, Chris G. Dealwis
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-06-01
Serier:Biomolecules
Fag:
ribonucleotide reductase
ribonucleotide reductase inhibitors
cancer chemotherapy
small molecule
drug discovery
hydrazone
Online adgang:https://www.mdpi.com/2218-273X/12/6/815
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