Oligomerization and Conformational Change Turn Monomeric β-Amyloid and Tau Proteins Toxic: Their Role in Alzheimer’s Pathogenesis

The structural polymorphism and the physiological and pathophysiological roles of two important proteins, β-amyloid (Aβ) and tau, that play a key role in Alzheimer’s disease (AD) are reviewed. Recent results demonstrate that monomeric Aβ has important physiological functions. Toxic oligomeric Aβ ass...

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Principais autores:	Botond Penke, Mária Szűcs, Ferenc Bogár
格式:	Artigo
語言:	Inglês
出版:	MDPI AG 2020-04-01
叢編:	Molecules
主題:	Alzheimer’s disease amyloid β oligomers tau oligomers physiological actions pathophysiology amyloid formation
在線閱讀:	https://www.mdpi.com/1420-3049/25/7/1659
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