Identification of Splicing Quantitative Trait Loci (sQTL) in Drosophila melanogaster with Developmental Lead (Pb2+) Exposure

Lead (Pb) poisoning has been a major public health issue globally and the recent Flint water crisis has drawn nation-wide attention to its effects. To better understand how lead plays a role as a neurotoxin, we utilized the Drosophila melanogaster model to study the genetic effects of lead exposure...

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Bibliographic Details

Main Authors:	Wen Qu, Katherine Gurdziel, Roger Pique-Regi, Douglas M. Ruden
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2017-10-01
Series:	Frontiers in Genetics
Subjects:	developmental lead exposure Drosophila melanogaster splicing quantitative trait loci (sQTL or splice QTL) Drosophila synthetic population resource (DSPR) RNA-seq toxicogenomics
Online Access:	http://journal.frontiersin.org/article/10.3389/fgene.2017.00145/full
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