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Susceptibility to acute cognitive dysfunction in aged mice is underpinned by reduced white matter integrity and microgliosis

Abstract Age is a significant but heterogeneous risk factor for acute neuropsychiatric disturbances such as delirium. Neuroinflammation increases with aging but the determinants of underlying risk for acute dysfunction upon systemic inflammation are not clear. We hypothesised that, with advancing ag...

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Hauptverfasser: Dáire Healy, Carol Murray, Ciara McAdams, Ruth Power, Pierre-Louis Hollier, Jessica Lambe, Lucas Tortorelli, Ana Belen Lopez-Rodriguez, Colm Cunningham
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2024-01-01
Schriftenreihe:Communications Biology
Online-Zugang:https://doi.org/10.1038/s42003-023-05662-9
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