Telomeric repeats in the commercial SB-1 vaccine facilitate viral integration and contribute to vaccine efficacy
Abstract Marek’s disease virus (MDV) integrates its genome into the telomeres of host chromosomes and causes fatal lymphomas in chickens. This integration is facilitated by telomeric repeat sequences (TMRs) at the ends of the viral genome, and is crucial for MDV-induced lymphomagenesis. The SB-1 vac...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Portfolio
2024-08-01
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| Series: | npj Vaccines |
| Online Access: | https://doi.org/10.1038/s41541-024-00945-6 |
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