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Population Pharmacokinetics of Phosphocreatine and Its Metabolite Creatine in Children With Myocarditis

Objective: This study aimed to develop a parent-metabolite joint population pharmacokinetic model to characterize the pharmacokinetic (PK) profile for phosphocreatine (PCr) and its metabolite creatine (Cr) in children with myocarditis and to use this model to study the PK profile of different dosing...

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Hlavní autoři: Huan He, Meng Zhang, Li-bo Zhao, Ning Sun, Yi Zhang, Yue Yuan, Xiao-ling Wang
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020-11-01
Edice:Frontiers in Pharmacology
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On-line přístup:https://www.frontiersin.org/articles/10.3389/fphar.2020.574141/full
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