Spliceread: improving canonical and non-canonical splice site prediction with residual blocks and synthetic data augmentation

Abstract Accurate splice site prediction is fundamental to understanding gene expression and its associated disorders. However, most existing models are biased toward frequent canonical sites, limiting their ability to detect rare but biologically important non-canonical variants. These models often...

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Prif Awduron:	Sahil Thapa, Khushali Samderiya, Rohit Menon, Oluwatosin Oluwadare
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	BMC 2026-05-01
Cyfres:	BMC Bioinformatics
Pynciau:	Splice site prediction Non-canonical sequences Transcriptomic Deep learning Residual CNN Data augmentation
Mynediad Ar-lein:	https://doi.org/10.1186/s12859-026-06486-0
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