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Chromosome anomalies in bone marrow as primary cause of aplastic or hypoplastic conditions and peripheral cytopenia: disorders due to secondary impairment of <it>RUNX1</it> and <it>MPL</it> genes

<p>Abstract</p> <p>Background</p> <p>Chromosome changes in the bone marrow (BM) of patients with persistent cytopenia are often considered diagnostic for a myelodysplastic syndrome (MDS). Comprehensive cytogenetic evaluations may give evidence of the real pathogenetic role of these changes in cases...

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Auteurs principaux: Marletta Cristina, Valli Roberto, Pressato Barbara, Mare Lydia, Montalbano Giuseppe, Menna Giuseppe, Loffredo Giuseppe, Bernardo Maria, Vinti Luciana, Ferrari Simona, Di Cesare-Merlone Alessandra, Zecca Marco, Lo Curto Francesco, Locatelli Franco, Pasquali Francesco, Maserati Emanuela
Format: Artigo
Langue:Inglês
Publié: BMC 2012-10-01
Collection:Molecular Cytogenetics
Sujets:
SAA
Thrombocytopenia
CAMT
<it>RUNX1</it>
<it>MPL</it>
Chromosome structural anomalies
Chromosome 1
Chromosome 21
Accès en ligne:http://www.molecularcytogenetics.org/content/5/1/39
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