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FTO-mediated DSP m6A demethylation promotes an aggressive subtype of growth hormone-secreting pituitary neuroendocrine tumors

Abstract Background Growth hormone-secreting pituitary neuroendocrine tumors can be pathologically classified into densely granulated (DGGH) and sparsely granulated types (SGGH). SGGH is more aggressive and associated with a poorer prognosis. While epigenetic regulation is vital in tumorigenesis and...

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Kaydedildi:
Asıl Yazarlar: Yunzhi Zou, Xiaoqiong Bao, Depei Li, Zhen Ye, Rong Xiang, Yuanzhong Yang, Zhe Zhu, Ziming Chen, Lingxing Zeng, Chunling Xue, Hongzhe Zhao, Boyuan Yao, Qilin Zhang, Zeming Yan, Zekun Deng, Jintong Cheng, Guanghao Yue, Wanming Hu, Jixiang Zhao, Ruihong Bai, Zhenhua Zhang, Aiqun Liu, Jialiang Zhang, Zhixiang Zuo, Xiaobing Jiang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMC 2024-09-01
Seri Bilgileri:Molecular Cancer
Konular:
Growth hormone-secreting pituitary neuroendocrine tumors
Pathological classification
N6-methyladenosine
Desmosome
Online Erişim:https://doi.org/10.1186/s12943-024-02117-5
Etiketler: Etiketle
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