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Penetrance estimates for <it>BRCA1 </it>and <it>BRCA2 </it>based on genetic testing in a Clinical Cancer Genetics service setting: Risks of breast/ovarian cancer quoted should reflect the cancer burden in the family

<p>Abstract</p> <p>Background</p> <p>The identification of a <it>BRCA1 </it>or <it>BRCA2 </it>mutation in familial breast cancer kindreds allows genetic testing of at risk relatives. However, considerable controversy exists regarding the cancer risks in women who test positive for the family mutatio...

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Principais autores: Lalloo Fiona, Woodward Emma, Shenton Andrew, Evans D Gareth, Howell Anthony, Maher Eamonn R
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2008-05-01
coleção:BMC Cancer
Acesso em linha:http://www.biomedcentral.com/1471-2407/8/155
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