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Causal inference and mediating pathways of metabolic syndrome on calcific aortic valve stenosis: linkage disequilibrium score regression and two-sample, two-step mendelian randomization study

Abstract Background Current evidence regarding the role of Metabolic Syndrome (MetS) and its components in Calcific Aortic Valve Stenosis (CAVS) remains limited and inconsistent. To elucidate the causal relationship and investigate potential mediators, we conducted Linkage Disequilibrium Score Regre...

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Principais autores: Shu Yang, Zhiqiang Bai, Xiangqing Ye, Sike Mo, Jianeng Chen, Minghuang Zhang, Dingyi Zhu, Minghua Zhu
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-03-01
Serier:Journal of Cardiothoracic Surgery
Fag:
Metabolic syndrome
Aortic valve stenosis
Linkage Disequilibrium Score Regression
Mendelian randomization
Metabolite
Online adgang:https://doi.org/10.1186/s13019-026-03952-x
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