Deciphering the secrets of tumor-initiating cells in pancreatic ductal adenocarcinoma microenvironment: mechanisms and therapeutic opportunities

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by poor prognosis, strong resistance to therapy, and a dense immunosuppressive tumor microenvironment (TME). A small subset of cells known as cancer stem cells (CSCs), or tumor-initiating cells (TICs), are increa...

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Główni autorzy:	Jun Zhou, Jiajun Li, Haoyi Lu, Yanggang Hong
Format:	Artigo
Język:	Inglês
Wydane:	Frontiers Media S.A. 2025-08-01
Seria:	Frontiers in Immunology
Hasła przedmiotowe:	pancreatic ductal adenocarcinoma tumor-initiating cell cancer stem cell tumor microenvironment immune evasion
Dostęp online:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1614707/full
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