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DON in pediatric cerebral malaria, a phase I/IIA dose-escalation safety study: study protocol for a clinical trial 

Abstract Background Despite treatment with highly effective antimalarial drugs, malaria annually claims the lives of over half a million children under 5-years of age in sub-Saharan Africa. Cerebral malaria (CM), defined as Plasmodium falciparum infection with coma, is the severe malaria syndrome wi...

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Principais autores: Nginache Nampota-Nkomba, Osward M. Nyirenda, Jane Mallewa, Yamikani Chimalizeni, Nettie Dzabala, Michael P. Fay, Mathangi Gopalakrishnan, Matthew B. Laurens, Nicole F. O’Brien, Louis H. Miller, Susan K. Pierce, Brittany A. Riggle, Douglas G. Postels
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-01-01
Serier:Trials
Fag:
6-Diazo-5-oxo-L-norleucine
DON
Glutamine antagonist
Cerebral malaria
Malaria
Plasmodium falciparum
Online adgang:https://doi.org/10.1186/s13063-023-07808-w
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