The dysregulated unfolded protein response in diabetic kidney disease: mechanisms and crosstalk with cell death pathways

Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage kidney failure worldwide, yet the molecular mechanisms driving progressive renal injury remain incompletely understood. Chronic metabolic stress in diabetes disrupts endoplasmic reticulum (ER) homeostasis, lea...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Hao Zhang, Kaixiang Li, Jia Ma, Ling Ma, Muhammad Asad Farooq, Jing E
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-06-01
Schriftenreihe:	Frontiers in Pharmacology
Schlagworte:	apoptosis diabetic kidney disease (DKD) ER stress ER-phagy ferroptosis unfolded protein response (UPR)
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1875777/full
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