Investigating Treatment Response in Obsessive–Compulsive Disorder Through Neuromodulation and Patient-Derived Induced Pluripotent Stem Cell Models: Preliminary Clinical Observations from a Translational Study

Background: Treatment-resistant obsessive–compulsive disorder (OCD) is a heterogeneous and clinically challenging condition. Growing evidence suggests alterations in glutamatergic signaling within cortico–striatal–thalamo–cortical circuits, including those involving medium spiny neurons (MSNs), as w...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Beatrice Benatti, Matteo Marcatili, Rodolfo Leuzzi, Massimo Clerici, Luciano Conti, Massimo Gennarelli, Carlo Sala, Federico Bernoni d’Aversa, Valentina Casati, Michele Castiglioni, Camilla Gesi, Nicolaja Girone, Luca Larini, Alessandra Minelli, Emma Rinaldi, Matteo Vismara, Bernardo Dell’Osso
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-05-01
coleção:	Brain Sciences
Assuntos:	obsessive–compulsive disorder treatment-resistant OCD neuromodulation transcranial magnetic stimulation induced pluripotent stem cells medium spiny neurons
Acesso em linha:	https://www.mdpi.com/2076-3425/16/5/537
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!