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Deletion of the Transcriptional Coactivator HCF-1 In Vivo Impairs the Removal of Repressive Heterochromatin from Latent HSV Genomes and Suppresses the Initiation of Viral Reactivation

ABSTRACT Transcription of herpes simplex virus 1 (HSV-1) immediate early (IE) genes is controlled at multiple levels by the cellular transcriptional coactivator, HCF-1. HCF-1 is complexed with epigenetic factors that prevent silencing of the viral genome upon infection, transcription factors that dr...

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Principais autores: Jesse H. Arbuckle, Jodi L. Vogel, Stacey Efstathiou, Thomas M. Kristie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2023-02-01
coleção:mBio
Assuntos:
HCF-1
herpes simplex virus
latency
HSV reactivation
viral chromatin
Acesso em linha:https://journals.asm.org/doi/10.1128/mbio.03542-22
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