Engineering HSV-1 for oncolytic therapy: From molecular entry mechanisms to retargeting strategies

Oncolytic viruses (OVs) represent a cutting-edge approach to cancer immunotherapy, characterized by their ability to selectively infect and eliminate tumor cells while sparing healthy tissues. Among the diverse OVs, type 1 herpes simplex virus (HSV-1) stands out due to its robust oncolytic activity,...

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Detalhes bibliográficos

Principais autores:	Yufang Zou, Juan Tao, Yingzheng Gao, Jixuan Wang, Pengfei Wang, Jingyuan Yan, Zuqing Nie, Dewei Jiang, Xinwei Huang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	KeAi Communications Co., Ltd. 2026-03-01
Colecção:	Genes and Diseases
Assuntos:	Cell fusion Glycoprotein genetic engineering Herpes simplex virus type I Oncolytic virotherapy Systemic administration Tropism-retargeting
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2352304225002867
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