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Evolutionary relaxation and functional change of INSL3 and RXFP2 may underlie natural cryptorchidism in mammals

Abstract Cryptorchidism is a common congenital abnormality that increases infertility and testicular cancer risk in adulthood. However, a few mammals exhibit naturally undescended testes while maintaining normal reproduction. The mechanisms underlying this natural cryptorchidism remain unclear. Here...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Yu Zheng, Simin Chai, Cuijuan Zhong, Yixuan Sun, Shixia Xu, Wenhua Ren, Guang Yang
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Springer Nature 2025-11-01
Rangatū:EMBO Reports
Ngā marau:
Urunga tuihono:https://doi.org/10.1038/s44319-025-00636-w
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