Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity
Abstract Mitochondrial apoptosis is strictly controlled by BCL-2 family proteins through a subtle network of protein interactions. The tumor suppressor protein p53 triggers transcription-independent apoptosis through direct interactions with BCL-2 family proteins, but the molecular mechanism is not...
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| Autori principali: | , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2023-07-01
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| Serie: | Nature Communications |
| Accesso online: | https://doi.org/10.1038/s41467-023-40087-2 |
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