A versatile toolkit for CRISPR-Cas13-based RNA manipulation in Drosophila

Abstract Advances in CRISPR technology have immensely improved our ability to manipulate nucleic acids, and the recent discovery of the RNA-targeting endonuclease Cas13 adds even further functionality. Here, we show that Cas13 works efficiently in Drosophila, both ex vivo and in vivo. We test 44 dif...

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Principais autores:	Nhan Huynh, Noah Depner, Raegan Larson, Kirst King-Jones
格式:	Artigo
語言:	Inglês
出版:	BMC 2020-11-01
叢編:	Genome Biology
主題:	CRISPR Cas13 CasRX Drosophila RNA manipulation crRNA design
在線閱讀:	http://link.springer.com/article/10.1186/s13059-020-02193-y
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