TMEM120A maintains adipose tissue lipid homeostasis through ER CoA channeling

Abstract Efficient fatty acid (FA) re-esterification is essential for lipid homeostasis in adipocytes, yet the mechanisms coordinating Coenzyme A (CoA) availability at the endoplasmic reticulum (ER)—a major site of lipid synthesis—remain unclear. Here, we identify TMEM120A as an ER-resident CoA-bind...

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Auteurs principaux:	Yoon Keun Cho, Junhyuck Lee, Yujin L. Jeong, Minki Shim, Xuan Linh Mai, Chang Seomoon, Cheol Woon Jung, Yoon Ha Choi, Sik Namgoong, Young-Suk Jung, Sung Won Kwon, Juyong Lee, Je Kyung Seong, Sunghyouk Park, Emilio P. Mottillo, James G. Granneman, Dong-Kyu Lee, Jong Kyoung Kim, Yun-Hee Lee
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2025-12-01
Collection:	Nature Communications
Accès en ligne:	https://doi.org/10.1038/s41467-025-67870-7
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