HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation.

Gene expression programs determine cell fate in embryonic development and their dysregulation results in disease. Transcription factors (TFs) control gene expression by binding to enhancers, but how TFs select and activate their target enhancers is still unclear. HOX TFs share conserved homeodomains...

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Hlavní autoři:	Laure Bridoux, Peyman Zarrineh, Joshua Mallen, Mike Phuycharoen, Victor Latorre, Frank Ladam, Marta Losa, Syed Murtuza Baker, Charles Sagerstrom, Kimberly A Mace, Magnus Rattray, Nicoletta Bobola
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2020-12-01
Edice:	PLoS Genetics
On-line přístup:	https://doi.org/10.1371/journal.pgen.1009162
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