SEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet α cells

Abstract Proteolytic cleavage of proglucagon by prohormone convertase 2 (PC2) is required for islet α cells to generate glucagon. However, the regulatory mechanisms underlying this process remain largely unclear. Here, we report that SEL1L-HRD1 endoplasmic reticulum (ER)-associated degradation (ERAD...

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Principais autores:	Wenzhen Zhu, Linxiu Pan, Xianwei Cui, Anna Chiara Russo, Rohit Ray, Brent Pederson, Xiaoqiong Wei, Liangguang Leo Lin, Mauricio Torres, Hannah Hafner, Brigid Gregg, Neha Shrestha, Chengyang Liu, Ali Naji, Peter Arvan, Darleen A. Sandoval, Iris Lindberg, Ling Qi, Rachel Byerley Reinert
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2026-02-01
Series:	Nature Communications
Acceso en liña:	https://doi.org/10.1038/s41467-026-69928-6
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