Ascorbic acid enhances antidepressant-like efficacy of esketamine: Hippocampal TARP-γ8-containing AMPA receptors mediate synaptic modulation

Ketamine exhibits superior efficacy compared to conventional antidepressants, yet its clinical application remains limited by dose-dependent side effects. Ascorbic acid (AA) augments ketamine’s antidepressant-like effects, suggesting that AA co-administration with subtherapeutic ketamine doses may a...

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Autors principals:	Zhaojuan Ke, Ying Zhang, Xin Jiang, Jie Luo, Hengsheng Chen, Yao Ma, Qibin Chen, Li Zhao, Binyang Cai
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2026-01-01
Col·lecció:	Neurotherapeutics
Matèries:	Ketamine Ascorbic acid AMPA receptor Synapse Depression
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S1878747925002648
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