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Dynamics of Th1/Th17 responses and antimicrobial pathways in leprosy skin lesions

BACKGROUND Reversal reactions (RRs) in leprosy are acute immune episodes marked by inflammation and bacterial clearance, offering a model to study the dynamics of host responses to Mycobacterium leprae. These episodes are often severe and difficult to treat, frequently progressing to permanent disab...

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Autors principals: Priscila R. Andrade, Feiyang Ma, Jing Lu, Jaime de Anda, Ernest Y. Lee, George W. Agak, Craig J. Dobry, Bruno J. de Andrade Silva, Rosane M.B. Teles, Lilah A. Mansky, Jonathan Perrie, Dennis J. Montoya, Bryan D. Bryson, Johann E. Gudjonsson, Gerard C.L. Wong, Euzenir N. Sarno, Matteo Pellegrini, Robert L. Modlin
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2025-09-01
Col·lecció:The Journal of Clinical Investigation
Matèries:
Immunology
Infectious disease
Accés en línia:https://doi.org/10.1172/JCI190736
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