Down-Regulation of PERK-ATF4-CHOP Pathway by Astragaloside IV is Associated with the Inhibition of Endoplasmic Reticulum Stress-Induced Podocyte Apoptosis in Diabetic Rats

Background: Endoplasmic reticulum (ER) stress-induced podocyte apoptosis plays a critical role in the development of diabetic nephropathy (DN). Here, we tested the hypothesis that suppression of PERK-ATF4-CHOP pathway by Astragaloside IV (AS-IV) is associated with inhibition of ER stress-induced pod...

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Hlavní autoři:	Yifang Chen, Dingkun Gui, Jianguo Chen, Dongyuan He, Yunling Luo, Niansong Wang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Cell Physiol Biochem Press GmbH & Co KG 2014-06-01
Edice:	Cellular Physiology and Biochemistry
Témata:	Astragaloside IV Endoplasmic reticulum stress PERK-ATF4-CHOP pathway Podocyte apoptosis Diabetic nephropathy
On-line přístup:	http://www.karger.com/Article/FullText/362974
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