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Digital PCR linkage analysis resolves Streptococcus pneumoniae signature from commensal interference in saliva samples: identifying wolves among sheep in wolf’s clothing

ABSTRACT Serotyping of Streptococcus pneumoniae (pneumococcus) is essential for evaluating the effects of conjugate polysaccharide vaccines on asymptomatic colonization (carriage) of vaccine-targeted capsular variants (serotypes). However, culture-independent application of molecular methods is hamp...

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Asıl Yazarlar: Willem R. Miellet, Tessa Nieuwenhuijsen, Eline H. M. R. van den Oetelaar, Janieke van Veldhuizen, Nynke Y. Rots, Krzysztof Trzciński, Rob Mariman
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2026-05-01
Seri Bilgileri:Microbiology Spectrum
Konular:
digital PCR
linkage
Streptococcus pneumoniae
saliva
serotyping
vaccine
Online Erişim:https://journals.asm.org/doi/10.1128/spectrum.03131-25
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