Lost in translation: absence of KIAA1324/ELAPOR1 protein in pathological TDP-43-affected neurons in ALS/FTD

Abstract Background Amyotrophic lateral sclerosis (ALS) is a movement disorder lacking effective diagnostics and therapeutics, largely due to its clinical and etiological heterogeneity. The unifying hallmark of TDP-43 pathology is found in approximately 97% of ALS patients, and 50% of frontotemporal...

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Detalhes bibliográficos

Principais autores:	Maize C. Cao, Molly E. V. Swanson, Indranil Basak, Kirstin McDonald, Frederick J. Arnold, Cameron M. Stockford, George Guo, Maurice A. Curtis, Richard L. M. Faull, Stephanie M. Hughes, Albert R. La Spada, Michael Dragunow, Emma L. Scotter
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-02-01
coleção:	Acta Neuropathologica Communications
Assuntos:	Amyotrophic lateral sclerosis Motor neuron disease TDP-43 Frontotemporal dementia KIAA1324 ELAPOR1
Acesso em linha:	https://doi.org/10.1186/s40478-026-02237-7
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