L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion

The molecular sensors underlying nutrient-stimulated GLP-1 secretion are currently being investigated. Peripheral administration of melanocortin-4 receptor (MC4R) agonists have been reported to increase GLP-1 plasma concentrations in mice and humans but it is unknown whether this effect results from...

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Autors principals:	Rune E. Kuhre, Ida M. Modvig, Sara L. Jepsen, Hüsün S. Kizilkaya, Cecilie Bæch-Laursen, Christopher A. Smith, Frank Reimann, Fiona M. Gribble, Mette M. Rosenkilde, Jens J. Holst
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2021-08-01
Col·lecció:	Frontiers in Endocrinology
Matèries:	alpha-MSH melanocortin melanocortin-4-receptor glucagon-like peptide-1 secretion L-cells
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fendo.2021.690387/full
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