NDR1 mediates PD-L1 deubiquitination to promote prostate cancer immune escape via USP10

Abstract Prostate cancer (PCa) is one of the most common male genitourinary system malignancies. Despite the significant benefits of anti-PD-L1 immune checkpoint inhibitor therapy in other cancers, the reasons for its poor therapeutic efficacy in prostate cancer (PCa) remain unclear.NDR1 plays an im...

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Huvudupphov:	Meiling Fu, Jinxin Li, Zuodong Xuan, Zeyuan Zheng, Yankuo Liu, Zeyi Zhang, Jianzhong Zheng, Min Zhong, Bin Liu, Yifan Du, Lei Zhang, Huimin Sun
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	BMC 2024-09-01
Serie:	Cell Communication and Signaling
Ämnen:	Prostate cancer NDR1/STK38, PD-L1 Immune escape Immune checkpoint Blockade Anti-PD-1 therapy
Länkar:	https://doi.org/10.1186/s12964-024-01805-5
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