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Therapeutic potential of low-dose rosiglitazone in periodontitis: attenuation of inflammation and bone loss through macrophage reprogramming

Abstract Objectives This study aimed to investigate the effects of different dosages of the peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist rosiglitazone on macrophage polarization, the expression of related inflammatory factors, and alveolar bone loss in the periodontal tissues of...

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Bibliographic Details
Main Authors: Li-Na Zhou, Zheng Zhang, Zhi-Tao Wang
Format: Artigo
Language:Inglês
Published: BMC 2026-04-01
Series:BMC Oral Health
Subjects:
Online Access:https://doi.org/10.1186/s12903-026-08251-4
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