Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection.

Uropathogenic E. coli (UPEC) is the primary cause of urinary tract infections (UTI) affecting approximately 150 million people worldwide. Here, we revealed the importance of transcriptional regulator hypoxia-inducible factor-1 α subunit (HIF-1α) in innate defense against UPEC-mediated UTI. The effec...

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Detalhes bibliográficos

Principais autores:	Ann E Lin, Federico C Beasley, Joshua Olson, Nadia Keller, Robert A Shalwitz, Thomas J Hannan, Scott J Hultgren, Victor Nizet
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2015-04-01
coleção:	PLoS Pathogens
Acesso em linha:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004818&type=printable
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