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Deficiency of microglial Hv1 channel is associated with activation of autophagic pathway and ROS production in LPC-induced demyelination mouse model

Abstract Background Multiple sclerosis (MS) is an immune-mediated demyelinated disease of the central nervous system. Activation of microglia is involved in the pathogenesis of myelin loss. Objective This study is focused on the role of Hv1 in regulating demyelination and microglial activation throu...

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Príomhchruthaitheoirí: Man Chen, Lin-Lin Yang, Zi-Wei Hu, Chuan Qin, Luo-Qi Zhou, Ya-ling Duan, Dale B. Bosco, Long-Jun Wu, Ke-Bin Zhan, Sha-Bei Xu, Dai-Shi Tian
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: BMC 2020-11-01
Sraith:Journal of Neuroinflammation
Ábhair:
Rochtain ar líne:http://link.springer.com/article/10.1186/s12974-020-02020-y
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