Safety, Tolerability, Pharmacokinetics, and Concentration-QTc Analysis of Tetrodotoxin: A Randomized, Dose Escalation Study in Healthy Adults

Tetrodotoxin (TTX) is a highly specific voltage-gated sodium channel (VGSC) blocker in clinical evaluation as a peripheral-acting analgesic for chronic pain. This study presents the first published results of the safety including cardiac liability of TTX at therapeutic-relevant concentrations in twe...

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Bibliografische Detailangaben

Hauptverfasser:	Mojgan Kavoosi, Terry E. O’Reilly, Mehran Kavoosi, Peng Chai, Caroline Engel, Walter Korz, Christopher C. Gallen, Robert M. Lester
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2020-08-01
Schriftenreihe:	Toxins
Schlagworte:	tetrodotoxin pain analgesic QT interval ECG voltage-gated sodium channels
Online-Zugang:	https://www.mdpi.com/2072-6651/12/8/511
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