A rare germline mutation reverses the suppressive effect of GPC5 thereby promoting lung adenocarcinoma development and tumorigenesis

Background and ObjectiveGlypican-5 (GPC5) has been well-characterized as a tumor suppressor in lung adenocarcinoma (LUAD); however, the functional implications of its germline mutations in cancer pathogenesis remain largely unexplored. In this study, we identified and characterized a pathogenic GPC5...

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Detalhes bibliográficos

Principais autores:	Zhifa Zheng, Lina Zhao, Sen Zhao, Zhihong Wu, Nan Wu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-04-01
coleção:	Frontiers in Genetics
Assuntos:	lung adenocarcinoma (LUAD) familial lung cancer glypican-5 (GPC5) germline mutation epithelial-mesenchymal transition (EMT)
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fgene.2025.1582504/full
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