Non-Canonical Senescence Phenotype in Resistance to CDK4/6 Inhibitors in ER-Positive Breast Cancer

Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) have transformed the treatment landscape for estrogen receptor-positive (ER+) breast cancer, yet resistance remains a major clinical challenge. Although CDK4/6i induce G₁ arrest and therapy-induced senescence (TIS), the exact nature of this...

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Principais autores:	Aynura Mammadova, Yuan Gu, Ling Ruan, Sunil S. Badve, Yesim Gökmen-Polar
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-01-01
coleção:	Biomolecules
Assuntos:	breast cancer CDK4/6 inhibitors resistance to cancer therapies therapy-induced senescence
Acesso em linha:	https://www.mdpi.com/2218-273X/16/1/93
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