In LDL receptor-deficient mice, catabolism of remnant lipoproteins requires a high level of apoE but is inhibited by excess apoE

To investigate the quantitative requirement for apolipoprotein (apo) E in the clearance of lipoproteins via the non-low density lipoprotein (LDL) receptor mediated pathway, human APOE was overexpressed at various levels in the livers of mice deficient for both the endogenous Apoe and Ldlr genes (Apo...

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Hlavní autoři:	Ko Willems van Dijk, Bart J.M. van Vlijmen, H. Belinda van't Hof, Andre van der Zee, Silvia Santamarina-Fojo, Theo J.C. van Berkel, Louis M. Havekes, Marten H. Hofker
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 1999-02-01
Edice:	Journal of Lipid Research
Témata:	adenovirus-mediated gene transfer LDL receptor-related protein hypertriglyceridemia VLDL-triglyceride lipolysis hepatic VLDL triglyceride production
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S0022227520333745
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