HDAC inhibitors Tubastatin A and SAHA affect parasite cell division and are potential anti-Toxoplasma gondii chemotherapeutics

The redirectioning of drugs in the pharmaceutical market is a well-known practice to identify new therapies for parasitic diseases. The histone deacetylase inhibitors Tubastatin A (TST) and Suberoylanilide Hydroxamic Acid (SAHA), firstly developed for cancer treatment, are effective against protozoa...

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Detalhes bibliográficos

Principais autores:	Carlla Assis Araujo-Silva, Wanderley De Souza, Erica S. Martins-Duarte, Rossiane C. Vommaro
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2021-04-01
coleção:	International Journal for Parasitology: Drugs and Drug Resistance
Assuntos:	Toxoplasma gondii Histone deacetylase inhibitors Apicomplexa Anti-parasitic chemotherapy Endodyogeny
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211320720300518
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