n-Tuples on Scaffold Diversity Inspired by Drug Hybridisation to Enhance Drugability: Application to Cytarabine

A mathematical concept, n-tuples are originally applied to medicinal chemistry, especially with the creation of scaffold diversity inspired by the hybridisation of different commercial drugs with cytarabine, a synthetic arabinonucleoside derived from two marine natural products, spongouridine and sp...

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Autori principali:	Miguel García-Castro, David Fuentes-Rios, J. Manuel López-Romero, Antonio Romero, Federico Moya-Utrera, Amelia Díaz-Morilla, Francisco Sarabia
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2023-12-01
Serie:	Marine Drugs
Soggetti:	scaffold diversity dual drugs chemical space arabinonucleosides n-duples
Accesso online:	https://www.mdpi.com/1660-3397/21/12/637
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