Differentiation block in acute myeloid leukemia regulated by intronic sequences of FTO

Summary: Iroquois transcription factor gene IRX3 is highly expressed in 20–30% of acute myeloid leukemia (AML) and contributes to the pathognomonic differentiation block. Intron 8 FTO sequences ∼220kB downstream of IRX3 exhibit histone acetylation, DNA methylation, and contacts with the IRX3 promote...

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主要な著者:	Francesco Camera, Isabel Romero-Camarero, Bradley H. Revell, Fabio M.R. Amaral, Oliver J. Sinclair, Fabrizio Simeoni, Daniel H. Wiseman, Lovorka Stojic, Tim C.P. Somervaille
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2023-08-01
シリーズ:	iScience
主題:	Molecular mechanism of gene regulation Epigenetics Cancer Transcriptomics
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2589004223013962
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