DiffInvex identifies evolutionary shifts in driver gene repertoires during tumorigenesis and chemotherapy
Abstract Somatic cells can transform into tumors due to mutations, and the tumors further evolve towards increased aggressiveness and therapy resistance. We develop DiffInvex, a framework for identifying changes in selection acting on individual genes in somatic genomes, drawing on an empirical muta...
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| Hoofdauteurs: | , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Portfolio
2025-05-01
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| Reeks: | Nature Communications |
| Online toegang: | https://doi.org/10.1038/s41467-025-59397-8 |
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