CRISPR-Cas9 based gene editing of the immune checkpoint NKG2A enhances NK cell mediated cytotoxicity against multiple myeloma

Natural Killer (NK) cells are known for their high intrinsic cytotoxic capacity, and the possibility to be applied as ‘off-the-shelf’ product makes them highly attractive for cell-based immunotherapies. In patients with multiple myeloma (MM), an elevated number of NK cells has been correlated with h...

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Ngā kaituhi matua:	Tobias Bexte, Jamal Alzubi, Lisa Marie Reindl, Philipp Wendel, Ralf Schubert, Emilia Salzmann-Manrique, Ivana von Metzler, Toni Cathomen, Evelyn Ullrich
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Taylor & Francis Group 2022-12-01
Rangatū:	OncoImmunology
Ngā marau:	Genome editing CRISPR-Cas NK cells inhibitory receptors immunotherapy NKG2A
Urunga tuihono:	https://www.tandfonline.com/doi/10.1080/2162402X.2022.2081415
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!