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Single-sequence based gFET-aptasensors for the discrimination of apo- and holo-RBP4 in human serum

Abstract Retinol-binding protein 4 (RBP4) is a key transporter of all-trans-retinol (vitamin A), circulating in blood as either holo-RBP4 (retinol-bound) or apo-RBP4 (retinol-free). Dysregulated RBP4 levels, particularly an imbalance between apo- and holo-RBP4, have been implicated in a range of met...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Hu Xing, Runliu Li, Yiting Zhang, Soumya Rajpal, Grigory Bolotnikov, Daniel Gruber, Hans-Maximilian Ruzicka, Jakob Andersson, Anil Bozdogan, Anna Nele Herdina, Robert Strassl, Roger Hasler, Christoph Kleber, Wolfgang Knoll, Boris Mizaikoff, Ann-Kathrin Kissmann, Frank Rosenau
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2026-07-01
Schriftenreihe:Scientific Reports
Schlagworte:
Aptasensor
gFET
RBP4
Molecular dynamics
Molecular docking
Online-Zugang:https://doi.org/10.1038/s41598-026-62460-z
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